References
Artichoke
First Study
- Reference: American Botanical Council.
- Date: September 30, 2008
- Objective: Evaluate effect on plasma cholesterol concentration.
- Methodology: Randomized, double-blind, placebo-controlled study.
- Place: UK.
- Patients Number: 75 Adults
- Conclusion: Study indicates that consumption of 1280 mg ALE daily for 12 weeks has a modest but favorable statistically significant effect on plasma total cholesterol levels in hypercholesterolemic adults.


Second Study
- Reference: American Botanical Council.
- Date: 1998
- Objective: Benefits of ALE in hypercholesterolemic,
dyspepsia, and liver function. - Methodology: Randomized, double-blind, placebocontrolled study.
- Place: Multicenter Study.
- Patients Number: 557 Adults
- Conclusion: Study indicates that consumption of
1500 mg ALE daily for 43 days reduced cholesterol
synthesis in the liver.
• In related studies:
• ALE had hepatoprotective and 10 mg/ml ALE
protect hepatocytes from CCL4 toxicity in vitro.
• ALE also appears to stimulate tissue regeneration
& numbers of binuclear liver cells.


Curcuma (Turmeric)
First Study
- Reference: Acta Med Inodnes / PubMed
- Date: 2011
- Objective: Established & novel NF-KB inihibtors
effects on TLRS & HNSCC. - Methodology: Prospective Study
- Place: Germany.
- Conclusion: Curcumin has potent antiinflammatory effect and strong inhibition
effect on NF-KB pathway


Second Study
- Reference: Acta Med Inodnes / PubMed
- Date: 2008
- Objective: Effect of curcumin on lipid level in
patients with acute coronary syndrome. - Methodology: Randomized, double-blind, placebocontrolled study.
- Place: Indonesia
- Patients Number: 557 Adults
- Conclusion: Administration of low-dose
curcumin showed a trend of reduction in
total cholesterol level & LDL cholesterol
levels in ASC patients.


Liquorice
First Study
- Reference: Pyhtother Res / PubMed
- Date: 2012
- Objective: Efficacy of liquorice root extract in
decreasing transaminase activities in NAFLD. - Methodology: Randomized, double-blind, placebocontrolled study.
- Place: Iran.
- Patients Number: 66 Adults.
- Conclusion: Administration of liquorice
root extract (2gm) for 2 months has
significant impact on ALT & AST with
statistical significance


Second Study
- Reference: Oncology
- Date: 2002
- Objective: Preventing liver cirrhosis & HCC with
glycyrrhizin (SNMC). - Methodology: Multiple.
- Place: Japan.
- Patients Number:Multiple
- Conclusion: Administration of low-dose
curcumin showed a trend of reduction in
total cholesterol level & LDL cholesterol
levels in ASC patients.


Milk Thistle (Mariana 90)
First Study
- Reference: American Botanical Council
- Date: 2005
- Objective: Silymarin in the treatment of liver
disease. - Methodology: Conservative Meta Analysis.


Second Study
- Reference: American Botanical Council
- Date: 2008
- Objective: Silymarin as an adjunctive therapy in
chemotherapy.


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