References

Artichoke

First Study

Reference: American Botanical Council.
Date: September 30, 2008
Objective: Evaluate effect on plasma cholesterol concentration.
Methodology: Randomized, double-blind, placebo-controlled study.
Place: UK.
Patients Number: 75 Adults

Conclusion: Study indicates that consumption of 1280 mg ALE daily for 12 weeks has a modest but favorable statistically significant effect on plasma total cholesterol levels in hypercholesterolemic adults.

Second Study

Reference: American Botanical Council.
Date: 1998
Objective: Benefits of ALE in hypercholesterolemic,
dyspepsia, and liver function.
Methodology: Randomized, double-blind, placebocontrolled study.
Place: Multicenter Study.
Patients Number: 557 Adults

Conclusion: Study indicates that consumption of
1500 mg ALE daily for 43 days reduced cholesterol
synthesis in the liver.
• In related studies:
• ALE had hepatoprotective and 10 mg/ml ALE
protect hepatocytes from CCL4 toxicity in vitro.
• ALE also appears to stimulate tissue regeneration
& numbers of binuclear liver cells.

Curcuma (Turmeric)

First Study

Reference: Acta Med Inodnes / PubMed
Date: 2011
Objective: Established & novel NF-KB inihibtors
effects on TLRS & HNSCC.
Methodology: Prospective Study
Place: Germany.

Conclusion: Curcumin has potent antiinflammatory effect and strong inhibition
effect on NF-KB pathway

Second Study

Reference: Acta Med Inodnes / PubMed
Date: 2008
Objective: Effect of curcumin on lipid level in
patients with acute coronary syndrome.
Methodology: Randomized, double-blind, placebocontrolled study.
Place: Indonesia
Patients Number: 557 Adults

Conclusion: Administration of low-dose
curcumin showed a trend of reduction in
total cholesterol level & LDL cholesterol
levels in ASC patients.

Liquorice

First Study

Reference: Pyhtother Res / PubMed
Date: 2012
Objective: Efficacy of liquorice root extract in
decreasing transaminase activities in NAFLD.
Methodology: Randomized, double-blind, placebocontrolled study.
Place: Iran.
Patients Number: 66 Adults.

Conclusion: Administration of liquorice
root extract (2gm) for 2 months has
significant impact on ALT & AST with
statistical significance

Second Study

Reference: Oncology
Date: 2002
Objective: Preventing liver cirrhosis & HCC with
glycyrrhizin (SNMC).
Methodology: Multiple.
Place: Japan.
Patients Number:Multiple

Conclusion: Administration of low-dose
curcumin showed a trend of reduction in
total cholesterol level & LDL cholesterol
levels in ASC patients.

Milk Thistle (Mariana 90)

First Study

Reference: American Botanical Council
Date: 2005
Objective: Silymarin in the treatment of liver
disease.
Methodology: Conservative Meta Analysis.

Second Study

Reference: American Botanical Council
Date: 2008
Objective: Silymarin as an adjunctive therapy in
chemotherapy.

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